Amir Ashoorzadeh: search on Z-Library

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1

Rational design of an AKR1C3-resistant analog of PR-104 for enzyme-prodrug therapy

Mowday, Alexandra M., Ashoorzadeh, Amir, Williams, Elsie M., Copp, Janine N., Silva, Shevan, Bull, Matthew R., Abbattista, Maria R., Anderson, Robert F., Flanagan, Jack U., Guise, Christopher P., Acke

Journal:

Biochemical Pharmacology

Year:

2016

Language:

english

File:

PDF, 847 KB

english, 2016

2

Directed evolution of the B. subtilis nitroreductase YfkO improves activation of the PET-capable probe SN33623 and CB1954 prodrug

Rich, Michelle H., Sharrock, Abigail V., Ashoorzadeh, Amir, Patterson, Adam V., Smaill, Jeff B., Ackerley, David F.

Journal:

Biotechnology Letters

Year:

2020

File:

PDF, 1.09 MB

2020

3

Selective Treatment of Hypoxic Tumor Cells In Vivo: Phosphate Pre-Prodrugs of Nitro Analogues of the Duocarmycins

Dr. Moana Tercel, Graham J. Atwell, Dr. Shangjin Yang, Dr. Amir Ashoorzadeh, Dr. Ralph J. Stevenson, K. Jane Botting, Dr. Yongchuan Gu, Sunali Y. Mehta, Prof. William A. Denny, Prof. William R. Wilson

Journal:

Angewandte Chemie

Year:

2011

Language:

english

File:

PDF, 405 KB

english, 2011

4

Synthesis of substituted 5-bromomethyl-4-nitroimidazoles and use for the preparation of the hypoxia-selective multikinase inhibitor SN29966

Lu, Guo-Liang, Ashoorzadeh, Amir, Anderson, Robert F., Patterson, Adam V., Smaill, Jeff B.

Journal:

Year:

2013

Language:

english

File:

PDF, 759 KB

english, 2013

5

2-Oxo-3, 4-dihydropyrimido[4, 5- d ]pyrimidinyl derivatives as new irreversible pan fibroblast growth factor receptor (FGFR) inhibitors

Li, Xueqiang, Guise, Christopher P., Taghipouran, Rana, Yosaatmadja, Yuliana, Ashoorzadeh, Amir, Paik, Woo-Kyong, Squire, Christopher J., Jiang, Shuang, Luo, Jinfeng, Xu, Yong, Tu, Zheng-Chao, Lu, Xia

Journal:

European Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 2.15 MB

english, 2017

6

Selective Treatment of Hypoxic Tumor Cells In Vivo: Phosphate Pre-Prodrugs of Nitro Analogues of the Duocarmycins

Dr. Moana Tercel, Graham J. Atwell, Dr. Shangjin Yang, Dr. Amir Ashoorzadeh, Dr. Ralph J. Stevenson, K. Jane Botting, Dr. Yongchuan Gu, Sunali Y. Mehta, Prof. William A. Denny, Prof. William R. Wilson

Journal:

Angewandte Chemie International Edition

Year:

2011

Language:

english

File:

PDF, 394 KB

english, 2011

7

A Convergent Enantioselective Synthesis of the Anti-Malarial Agent (+)-Febrifugine

Ashoorzadeh, Amir, Caprio, Vittorio

Journal:

Year:

2005

Language:

english

File:

PDF, 84 KB

english, 2005

8

A Convergent Enantioselective Synthesis of the Antimalarial Agent (+)-Febrifugine.

Amir Ashoorzadeh, Vittorio Caprio

Journal:

Year:

2005

File:

PDF, 9 KB

2005

9

The effect of a bromide leaving group on the properties of nitro analogs of the duocarmycins as hypoxia-activated prodrugs and phosphate pre-prodrugs for antitumor therapy

Ralph J. Stevenson, William A. Denny, Amir Ashoorzadeh, Frederik B. Pruijn, Wouter F. van Leeuwen, Moana Tercel

Journal:

Bioorganic & Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 604 KB

english, 2011

10

Engineering Escherichia coli NfsB To Activate a Hypoxia-Resistant Analogue of the PET Probe EF5 To Enable Non-Invasive Imaging during Enzyme Prodrug Therapy

Williams, Elsie M., Rich, Michelle H., Mowday, Alexandra M., Ashoorzadeh, Amir, Copp, Janine N., Guise, Christopher P., Anderson, Robert F., Flanagan, Jack U., Smaill, Jeff B., Patterson, Adam V., Ack

Journal:

Year:

2019

Language:

english

File:

PDF, 3.19 MB

english, 2019

11

The effect of sulfonate leaving groups on the hypoxia-selective toxicity of nitro analogs of the duocarmycins

Amir Ashoorzadeh, Graham J. Atwell, Frederik B. Pruijn, William R. Wilson, Moana Tercel, William A. Denny, Ralph J. Stevenson

Journal:

Bioorganic & Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 651 KB

english, 2011

12

Engineering a Multifunctional Nitroreductase for Improved Activation of Prodrugs and PET Probes for Cancer Gene Therapy

Copp, Janine N., Mowday, Alexandra M., Williams, Elsie M., Guise, Christopher P., Ashoorzadeh, Amir, Sharrock, Abigail V., Flanagan, Jack U., Smaill, Jeff B., Patterson, Adam V., Ackerley, David F.

Journal:

Cell Chemical Biology

Year:

2017

Language:

english

File:

PDF, 3.67 MB

english, 2017

13

Creation and screening of a multi-family bacterial oxidoreductase library to discover novel nitroreductases that efficiently activate the bioreductive prodrugs CB1954 and PR-104A

Prosser, Gareth A., Copp, Janine N., Mowday, Alexandra M., Guise, Christopher P., Syddall, Sophie P., Williams, Elsie M., Horvat, Claire N., Swe, Pearl M., Ashoorzadeh, Amir, Denny, William A., Smaill

Journal:

Biochemical Pharmacology

Year:

2013

Language:

english

File:

PDF, 1.21 MB

english, 2013

14

Synthetic evaluation of an enantiopure tetrahydropyridine N-oxide. Synthesis of (+)-febrifugine

Amir Ashoorzadeh, Glenn Archibald, Vittorio Caprio

Journal:

Year:

2009

Language:

english

File:

PDF, 431 KB

english, 2009

15

ChemInform Abstract: Synthesis of Substituted 5-Bromomethyl-4-nitroimidazoles and Use for the Preparation of the Hypoxia-Selective Multikinase Inhibitor SN29966.

Lu, Guo-Liang, Ashoorzadeh, Amir, Anderson, Robert F., Patterson, Adam V., Smaill, Jeff B.

Journal:

Year:

2014

File:

PDF, 25 KB

2014

16

Planar chiral (η6-arene)tricarbonylchromium complexes derived from mandelic acid

Paul D Woodgate, Amir Ashoorzadeh, Ali Hosseini, Clifton E.F Rickard, Lee-Kei Yang

Journal:

Journal of Organometallic Chemistry

Year:

2002

Language:

english

File:

PDF, 220 KB

english, 2002

17

E. coli nitroreductase NfsA is a reporter gene for non-invasive PET imaging in cancer gene therapy applications

Mowday, Alexandra Marie, Copp, Janine Naomi, Syddall, Sophie Philippa, Dubois, Ludwig Jerome, Wang, Jingli, Lieuwes, Natasja Gabi, Biemans, Rianne, Ashoorzadeh, Amir, Abbattista, Maria Rosaria, Willia

Journal:

Year:

2020

File:

PDF, 1.62 MB

2020

18

Nitro seco Analogues of the Duocarmycins Containing Sulfonate Leaving Groups as Hypoxia-Activated Prodrugs for Cancer Therapy

Stevenson, Ralph J., Denny, William A., Tercel, Moana, Pruijn, Frederik B., Ashoorzadeh, Amir

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 1.86 MB

english, 2012

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